R98W (p.Arg98Trp) variant of CD8B (P10966)
R98W (p.Arg98Trp) in CD8B (P10966) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data and structural context.
R98W (p.Arg98Trp) variant details
- p.Arg98Trp
- rs755618216
- ExAC rs755618216
- TOPMed rs755618216
- gnomAD rs755618216
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.291
- REVEL 0.26
- MetaLR 0.45
- MetaSVM -0.72
- CADD 17.20
- PolyPhen-2 0.91
- SIFT 0.04
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available