R94W (p.Arg94Trp) variant of CD8B (P10966)
R94W (p.Arg94Trp) in CD8B (P10966) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data and structural context.
R94W (p.Arg94Trp) variant details
- p.Arg94Trp
- rs747895168
- NCI-TCGA Cosmic COSV5892
- cosmic curated COSV58924
- ExAC rs747895168
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.194
- REVEL 0.14
- MetaLR 0.41
- MetaSVM -0.87
- CADD 15.10
- PolyPhen-2 0.91
- SIFT 0.18
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the East Asian population (allele frequency 0.00019)
- Structural context available