IL33 (Interleukin-33) variants and mutations

IL33 (also known as Interleukin-33) is a human protein-coding gene encoding an interleukin-33 protein. It acts as an epithelial and stromal alarm signal released during tissue stress, activating type 2 immune responses through ST2-expressing cells. Excess IL-33 signaling contributes to asthma, allergy, and other inflammatory diseases. This analysis covers 583 IL33 variants and mutations. Of these, 85% have computational variant effect predictions. Disease context includes asthma, allergic disease, and allergic rhinitis. Example IL33 variants include K2*, K2N, and K2R.

Variant analysis overview

Gene: IL33
Protein: Interleukin-33
UniProt accession: O95760
Organism: Homo sapiens
Variants analyzed: 583
Variant scope: all variants
Completed: 2026-08-21

Variant and mutation evidence

Variant composition: 364 unspecified-consequence records; 108 missense variants; 82 synonymous variants; 13 frameshift variants; 13 stop-gained variants; 2 in-frame insertions; 2 splice-region variants; 1 in-frame deletions
Prediction scores: 496 variants have prediction scores (85% of the analyzed set).

Clinical, disease, and population context

Disease context: 25 disease associations are represented. Top associations: asthma, allergic disease, allergic rhinitis, respiratory system disorder, Wheezing, childhood onset asthma, chronic rhinosinusitis with nasal polyps, deep vein thrombosis, chronic rhinosinusitis, nasal cavity polyp, atopic IgE-mediated allergic disorder, sinusitis.

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, 3D Hotspot Analysis, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable IL33 variants

Examples include K2*, K2N, K2R, P3A, P3T, P3L, P3P, K4E. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.

IL33 analysis run — IL33 (583 variants) — completed 2026-08-21