G30E (p.Gly30Glu) variant of IL33 (Interleukin-33)
G30E (p.Gly30Glu) in IL33 (Interleukin-33) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; high impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.14 / 1. The record also includes population frequency data and structural context.
G30E (p.Gly30Glu) variant details
- p.Gly30Glu
- rs778800068
- NCI-TCGA TCGA novel
- NCI-TCGA Cosmic COSV6734
- cosmic curated COSV67342
- Variant assessed as somatic; high impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.141
- AlphaMissense 0.12
- MetaLR 0.05
- MetaSVM -1.05
- CADD 0.34
- PolyPhen-2 0.07
- SIFT 0.02
- UniProt: Variant assessed as somatic; high impact.
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available