S49C (p.Ser49Cys) variant of IL33 (Interleukin-33)
S49C (p.Ser49Cys) in IL33 (Interleukin-33) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.57 / 1. The record also includes population frequency data and structural context.
S49C (p.Ser49Cys) variant details
- p.Ser49Cys
- ExAC rs764666831
- TOPMed rs764666831
- gnomAD rs764666831
- Missense
- Variant Prioritization Score for Impact Estimate 0.57
- AlphaMissense 0.26
- MetaLR 0.34
- MetaSVM -0.22
- CADD 23.50
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Ashkenazi Jewish population (allele frequency 0.0012)
- Structural context available