K28N (p.Lys28Asn) variant of IL33 (Interleukin-33)
K28N (p.Lys28Asn) in IL33 (Interleukin-33) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data and structural context.
K28N (p.Lys28Asn) variant details
- p.Lys28Asn
- ExAC rs754861043
- TOPMed rs754861043
- gnomAD rs754861043
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.204
- AlphaMissense 0.36
- MetaLR 0.18
- MetaSVM -0.90
- CADD 7.19
- PolyPhen-2 0.84
- SIFT 0.00
- ClinVar: Uncertain significance (not specified)
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available