C26F (p.Cys26Phe) variant of IL33 (Interleukin-33)
C26F (p.Cys26Phe) in IL33 (Interleukin-33) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data and structural context.
C26F (p.Cys26Phe) variant details
- p.Cys26Phe
- ExAC rs755596629
- gnomAD rs755596629
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.202
- AlphaMissense 0.17
- MetaLR 0.07
- MetaSVM -1.00
- CADD 2.85
- PolyPhen-2 0.00
- SIFT 0.00
- ClinVar: Uncertain significance (not specified)
- UniProt: Uncertain significance
- Most common in the South Asian population (allele frequency 0.00033)
- Structural context available