L25S (p.Leu25Ser) variant of IL33 (Interleukin-33)
L25S (p.Leu25Ser) in IL33 (Interleukin-33) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data, published literature, and structural context.
L25S (p.Leu25Ser) variant details
- p.Leu25Ser
- gnomAD 9-6241768-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.197
- AlphaMissense 0.15
- MetaLR 0.13
- MetaSVM -1.00
- CADD 5.55
- PolyPhen-2 0.09
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 6e-05)
- Structural context available
- Literature evidence available