A15T (p.Ala15Thr) variant of IL33 (Interleukin-33)
A15T (p.Ala15Thr) in IL33 (Interleukin-33) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
A15T (p.Ala15Thr) variant details
- p.Ala15Thr
- rs865842230
- ClinGen CA188630783
- ClinVar RCV004228445
- TOPMed rs865842230
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.357
- AlphaMissense 0.10
- MetaLR 0.30
- MetaSVM -0.78
- CADD 21.70
- PolyPhen-2 1.00
- SIFT 0.00
- ClinVar: Uncertain significance (not specified)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the African/African-American population (allele frequency 9e-05)
- Structural context available