K11N (p.Lys11Asn) variant of IL33 (Interleukin-33)
K11N (p.Lys11Asn) in IL33 (Interleukin-33) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data and structural context.
K11N (p.Lys11Asn) variant details
- p.Lys11Asn
- rs769902678
- NCI-TCGA Cosmic COSV1011
- cosmic curated COSV10119
- ExAC rs769902678
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.319
- AlphaMissense 0.24
- MetaLR 0.16
- MetaSVM -0.93
- CADD 19.60
- PolyPhen-2 0.83
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Latino/Admixed American population (allele frequency 0.00025)
- Structural context available