S13F (p.Ser13Phe) variant of IL33 (Interleukin-33)

Name: IL33 S13F (p.Ser13Phe) variant | CATVariant
Creator: Center for Precision Medicine and Data Sciences
Published: 2026-08-21
License: https://catvariant.com/terms-of-use

S13F (p.Ser13Phe) in IL33 (Interleukin-33) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data and structural context.

S13F (p.Ser13Phe) variant details

p.Ser13Phe
NCI-TCGA Cosmic COSV6734
cosmic curated COSV67342
Variant assessed as somatic; moderate impact.
Missense
Variant Prioritization Score for Impact Estimate 0.429
AlphaMissense 0.18
MetaLR 0.28
MetaSVM -0.86
CADD 22.50
PolyPhen-2 0.98
SIFT 0.00
UniProt: Variant assessed as somatic; moderate impact.
Most common in the Middle Eastern population (allele frequency 0.00017)
Structural context available