LAG3 (P18627) variants and mutations

LAG3 (also known as P18627) is a human protein-coding gene encoding a lymphocyte activation gene 3 protein. It restrains activated and chronically stimulated T cells and contributes to immune tolerance and T-cell exhaustion. Its coexpression with other inhibitory receptors in tumors makes LAG-3 an established immune-checkpoint target in cancer therapy. This analysis covers 925 LAG3 variants and mutations. Of these, 84% have computational variant effect predictions. Disease context includes melanoma, non-small cell lung carcinoma, and colorectal cancer. Example LAG3 variants include W2R, W2C, and E3E.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, 3D Hotspot Analysis, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable LAG3 variants

Examples include W2R, W2C, E3E, A4A, Q5E, Q5*, F6L, L7L. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.