P46L (p.Pro46Leu) variant of LAG3 (P18627)
P46L (p.Pro46Leu) in LAG3 (P18627) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data and structural context.
P46L (p.Pro46Leu) variant details
- p.Pro46Leu
- ExAC rs777597742
- TOPMed rs777597742
- gnomAD rs777597742
- Missense
- Variant Prioritization Score for Impact Estimate 0.181
- REVEL 0.02
- CADD 18.20
- PolyPhen-2 0.01
- SIFT 0.22
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available