V61I (p.Val61Ile) variant of LAG3 (P18627)
V61I (p.Val61Ile) in LAG3 (P18627) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data and structural context.
V61I (p.Val61Ile) variant details
- p.Val61Ile
- ExAC rs770243423
- TOPMed rs770243423
- gnomAD rs770243423
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.198
- REVEL 0.05
- CADD 18.60
- PolyPhen-2 0.04
- SIFT 0.10
- ClinVar: Uncertain significance (not specified)
- UniProt: Uncertain significance
- Most common in the Latino/Admixed American population (allele frequency 6.5e-05)
- Structural context available