W33C (p.Trp33Cys) variant of LAG3 (P18627)
W33C (p.Trp33Cys) in LAG3 (P18627) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.47 / 1. The record also includes population frequency data and structural context.
W33C (p.Trp33Cys) variant details
- p.Trp33Cys
- NCI-TCGA Cosmic COSV5256
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.469
- REVEL 0.23
- CADD 28.90
- PolyPhen-2 0.63
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available