A38S (p.Ala38Ser) variant of LAG3 (P18627)
A38S (p.Ala38Ser) in LAG3 (P18627) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data and structural context.
A38S (p.Ala38Ser) variant details
- p.Ala38Ser
- rs751673910
- NCI-TCGA Cosmic COSV9917
- cosmic curated COSV99179
- ExAC rs751673910
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.163
- REVEL 0.07
- CADD 18.20
- PolyPhen-2 0.23
- SIFT 0.34
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available