P46S (p.Pro46Ser) variant of LAG3 (P18627)
P46S (p.Pro46Ser) in LAG3 (P18627) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data and structural context.
P46S (p.Pro46Ser) variant details
- p.Pro46Ser
- TOPMed rs1941863378
- Missense
- Variant Prioritization Score for Impact Estimate 0.193
- REVEL 0.05
- CADD 22.50
- PolyPhen-2 0.60
- SIFT 0.10
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available