OPRM1 (Mu-type opioid receptor) variants and mutations

OPRM1 (also known as Mu-type opioid receptor) is a human protein-coding gene encoding a mu-type opioid receptor protein. A G protein-coupled receptor for endogenous opioids and medicines such as morphine and fentanyl. Its activation changes neuronal signaling involved in pain, reward, and respiratory control through inhibitory G protein pathways. This analysis covers 924 OPRM1 variants and mutations. Of these, 74% have computational variant effect predictions. Disease context includes opiate dependence, Pain, and opioid use disorder. Example OPRM1 variants include M1?, M1V, and M1T.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, 3D Hotspot Analysis, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable OPRM1 variants

Examples include M1?, M1V, M1T, M1I, D2E, D2G, S3G, S3I. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.