S27R (p.Ser27Arg) variant of OPRM1 (Mu-type opioid receptor)
S27R (p.Ser27Arg) in OPRM1 (Mu-type opioid receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data, published literature, and structural context.
S27R (p.Ser27Arg) variant details
- p.Ser27Arg
- gnomAD 6-154039625-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.275
- REVEL 0.25
- MetaLR 0.07
- MetaSVM -1.06
- CADD 16.70
- PolyPhen-2 0.03
- SIFT 0.68
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available
- Literature evidence available