A18G (p.Ala18Gly) variant of OPRM1 (Mu-type opioid receptor)
A18G (p.Ala18Gly) in OPRM1 (Mu-type opioid receptor) is a missense change. Clinical records from EBI and UniProt describe it as drug response. The available variant effect predictions contribute to a CATVariant prioritization score of 0.08 / 1. The record also includes population frequency data and structural context.
A18G (p.Ala18Gly) variant details
- p.Ala18Gly
- 1000Genomes rs577345039
- ExAC rs577345039
- TOPMed rs577345039
- gnomAD rs577345039
- Drug response
- Missense
- Variant Prioritization Score for Impact Estimate 0.0836
- REVEL 0.06
- CADD 6.70
- PolyPhen-2 0.00
- SIFT 0.52
- EBI: Drug response
- UniProt: Drug response
- Most common in the South Asian population (allele frequency 0.00021)
- Structural context available