A18T (p.Ala18Thr) variant of OPRM1 (Mu-type opioid receptor)
A18T (p.Ala18Thr) in OPRM1 (Mu-type opioid receptor) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as likely benign in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.04 / 1. The record also includes population frequency data and structural context.
A18T (p.Ala18Thr) variant details
- p.Ala18Thr
- ESP rs111339162
- ExAC rs111339162
- TOPMed rs111339162
- gnomAD rs111339162
- Likely benign
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.0397
- REVEL 0.02
- CADD 0.42
- PolyPhen-2 0.00
- SIFT 0.60
- ClinVar: Likely benign (not specified)
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the African/African-American population (allele frequency 0.00048)
- Structural context available