T8R (p.Thr8Arg) variant of OPRM1 (Mu-type opioid receptor)
T8R (p.Thr8Arg) in OPRM1 (Mu-type opioid receptor) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; high impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.05 / 1. The record also includes population frequency data and structural context.
T8R (p.Thr8Arg) variant details
- p.Thr8Arg
- NCI-TCGA TCGA novel
- gnomAD rs1779597786
- Variant assessed as somatic; high impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.0495
- REVEL 0.04
- CADD 0.34
- PolyPhen-2 0.00
- SIFT 0.19
- UniProt: Variant assessed as somatic; high impact.
- Most common in the Latino/Admixed American population (allele frequency 6.7e-05)
- Structural context available