W31* (p.Trp31Ter) variant of OPRM1 (Mu-type opioid receptor)
W31* (p.Trp31Ter) in OPRM1 (Mu-type opioid receptor) is a protein-truncating change. Clinical records from UniProt describe it as variant assessed as somatic; high impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.68 / 1. The record also includes population frequency data and structural context.
W31* (p.Trp31Ter) variant details
- p.Trp31Ter
- NCI-TCGA Cosmic COSV5768
- cosmic curated COSV57682
- gnomAD rs1413027831
- Variant assessed as somatic; high impact.
- Stop Gained
- Variant Prioritization Score for Impact Estimate 0.676
- CADD 33.00
- UniProt: Variant assessed as somatic; high impact.
- Most common in the Ashkenazi Jewish population (allele frequency 3.8e-05)
- Structural context available