S35Y (p.Ser35Tyr) variant of OPRM1 (Mu-type opioid receptor)
S35Y (p.Ser35Tyr) in OPRM1 (Mu-type opioid receptor) is a missense change. Clinical records from ClinVar and UniProt describe it as drug response in the context of Tramadol response. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data and structural context.
S35Y (p.Ser35Tyr) variant details
- p.Ser35Tyr
- ExAC rs768405841
- TOPMed rs768405841
- gnomAD rs768405841
- drug response
- Tramadol response
- Missense
- Variant Prioritization Score for Impact Estimate 0.31
- CADD 9.07
- ClinVar: drug response (Tramadol response)
- UniProt: Drug response
- Most common in the Non-Finnish European population (allele frequency 9.3e-07)
- Structural context available