A5S (p.Ala5Ser) variant of OPRM1 (Mu-type opioid receptor)
A5S (p.Ala5Ser) in OPRM1 (Mu-type opioid receptor) is a missense change. Clinical records from EBI and UniProt describe it as likely benign. The available variant effect predictions contribute to a CATVariant prioritization score of 0.06 / 1. The record also includes population frequency data and structural context.
A5S (p.Ala5Ser) variant details
- p.Ala5Ser
- TOPMed rs1223121173
- gnomAD rs1223121173
- Likely benign
- Missense
- Variant Prioritization Score for Impact Estimate 0.0634
- REVEL 0.06
- CADD 0.02
- PolyPhen-2 0.00
- SIFT 0.49
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the African/African-American population (allele frequency 4.8e-05)
- Structural context available