A18V (p.Ala18Val) variant of OPRM1 (Mu-type opioid receptor)
A18V (p.Ala18Val) in OPRM1 (Mu-type opioid receptor) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as drug response in the context of Tramadol response. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data and structural context.
A18V (p.Ala18Val) variant details
- p.Ala18Val
- rs577345039
- ClinGen CA4061360
- cosmic curated COSV57674
- ClinVar RCV001029183
- drug response
- Tramadol response
- Missense
- Variant Prioritization Score for Impact Estimate 0.455
- CADD 15.60
- ClinVar: drug response (Tramadol response)
- EBI: Drug response
- UniProt: Drug response
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available