A10T (p.Ala10Thr) variant of OPRM1 (Mu-type opioid receptor)
A10T (p.Ala10Thr) in OPRM1 (Mu-type opioid receptor) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.11 / 1. The record also includes population frequency data and structural context.
A10T (p.Ala10Thr) variant details
- p.Ala10Thr
- TOPMed rs1425495037
- gnomAD rs1425495037
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.115
- REVEL 0.06
- CADD 6.27
- PolyPhen-2 0.00
- SIFT 0.69
- ClinVar: Uncertain significance (not specified)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 5.9e-05)
- Structural context available