T8M (p.Thr8Met) variant of OPRM1 (Mu-type opioid receptor)
T8M (p.Thr8Met) in OPRM1 (Mu-type opioid receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data, published literature, and structural context.
T8M (p.Thr8Met) variant details
- p.Thr8Met
- gnomAD 6-154039567-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.12
- REVEL 0.08
- MetaLR 0.01
- MetaSVM -1.07
- CADD 11.20
- PolyPhen-2 0.09
- SIFT 0.12
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available