T14S (p.Thr14Ser) variant of OPRM1 (Mu-type opioid receptor)
T14S (p.Thr14Ser) in OPRM1 (Mu-type opioid receptor) is a missense change. Clinical records from ClinVar and UniProt describe it as likely benign in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.09 / 1. The record also includes population frequency data and structural context.
T14S (p.Thr14Ser) variant details
- p.Thr14Ser
- gnomAD rs1457556221
- Likely benign
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.0926
- REVEL 0.07
- CADD 6.77
- PolyPhen-2 0.00
- SIFT 1.00
- ClinVar: Likely benign (not specified)
- UniProt: Likely benign
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available