A5T (p.Ala5Thr) variant of OPRM1 (Mu-type opioid receptor)
A5T (p.Ala5Thr) in OPRM1 (Mu-type opioid receptor) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as likely benign in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.05 / 1. The record also includes population frequency data and structural context.
A5T (p.Ala5Thr) variant details
- p.Ala5Thr
- rs1223121173
- ClinGen CA366152290
- cosmic curated COSV10000
- ClinVar RCV004237635
- Likely benign
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.054
- REVEL 0.05
- CADD 0.02
- PolyPhen-2 0.00
- SIFT 0.52
- ClinVar: Likely benign (not specified)
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the REMAINING population (allele frequency 0.00048)
- Structural context available