ROS1 (P08922) variants and mutations

ROS1 (also known as P08922) is a human protein-coding gene encoding a proto-oncogene tyrosine-protein kinase ROS protein. Its normal physiologic signaling remains incompletely defined, but chromosomal rearrangement can place its kinase domain under constitutive control. ROS1 fusion kinases are actionable oncogenic drivers in non-small-cell lung cancer and several other tumors. This analysis covers 5,943 ROS1 variants and mutations. Of these, 39% have computational variant effect predictions. Disease context includes non-small cell lung carcinoma, neoplasm, and lung adenocarcinoma. Example ROS1 variants include K2N, N3H, and I4F.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, 3D Hotspot Analysis, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable ROS1 variants

Examples include K2N, N3H, I4F, I4V, Y5F, Y5H, C6S, C6Y. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.