L41V (p.Leu41Val) variant of ROS1 (P08922)
L41V (p.Leu41Val) in ROS1 (P08922) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
L41V (p.Leu41Val) variant details
- p.Leu41Val
- cosmic curated COSV10747
- ExAC rs757365700
- gnomAD rs757365700
- Missense
- Variant Prioritization Score for Impact Estimate 0.233
- REVEL 0.13
- MetaLR 0.13
- MetaSVM -0.91
- CADD 18.90
- PolyPhen-2 0.01
- SIFT 0.08
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available