V25M (p.Val25Met) variant of ROS1 (P08922)
V25M (p.Val25Met) in ROS1 (P08922) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
V25M (p.Val25Met) variant details
- p.Val25Met
- ExAC rs776025396
- TOPMed rs776025396
- gnomAD rs776025396
- Missense
- Variant Prioritization Score for Impact Estimate 0.236
- REVEL 0.21
- MetaLR 0.09
- MetaSVM -1.05
- CADD 15.90
- PolyPhen-2 0.00
- SIFT 0.01
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available