C37S (p.Cys37Ser) variant of ROS1 (P08922)
C37S (p.Cys37Ser) in ROS1 (P08922) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.53 / 1. The record also includes population frequency data and structural context.
C37S (p.Cys37Ser) variant details
- p.Cys37Ser
- ExAC rs779056086
- Missense
- Variant Prioritization Score for Impact Estimate 0.531
- REVEL 0.52
- MetaLR 0.22
- MetaSVM -0.56
- CADD 23.10
- PolyPhen-2 0.31
- SIFT 0.00
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available