C57Y (p.Cys57Tyr) variant of ROS1 (P08922)
C57Y (p.Cys57Tyr) in ROS1 (P08922) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.54 / 1. The record also includes population frequency data and structural context.
C57Y (p.Cys57Tyr) variant details
- p.Cys57Tyr
- cosmic curated COSV63850
- TOPMed rs1775327594
- Missense
- Variant Prioritization Score for Impact Estimate 0.543
- REVEL 0.56
- MetaLR 0.22
- MetaSVM -0.63
- CADD 23.70
- PolyPhen-2 0.26
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available