C84Y (p.Cys84Tyr) variant of ROS1 (P08922)
C84Y (p.Cys84Tyr) in ROS1 (P08922) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.13 / 1. The record also includes population frequency data and structural context.
C84Y (p.Cys84Tyr) variant details
- p.Cys84Tyr
- ExAC rs753907292
- TOPMed rs753907292
- gnomAD rs753907292
- Missense
- Variant Prioritization Score for Impact Estimate 0.125
- REVEL 0.02
- MetaLR 0.17
- MetaSVM -0.88
- CADD 13.20
- PolyPhen-2 0.98
- SIFT 0.08
- Most common in the East Asian population (allele frequency 2.9e-05)
- Structural context available