L11R (p.Leu11Arg) variant of ROS1 (P08922)
L11R (p.Leu11Arg) in ROS1 (P08922) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data and structural context.
L11R (p.Leu11Arg) variant details
- p.Leu11Arg
- ExAC rs772804887
- TOPMed rs772804887
- gnomAD rs772804887
- Missense
- Variant Prioritization Score for Impact Estimate 0.176
- REVEL 0.20
- MetaLR 0.13
- MetaSVM -0.92
- CADD 6.53
- PolyPhen-2 0.00
- SIFT 0.02
- Most common in the Latino/Admixed American population (allele frequency 2.3e-05)
- Structural context available