G60E (p.Gly60Glu) variant of ROS1 (P08922)
G60E (p.Gly60Glu) in ROS1 (P08922) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.62 / 1. The record also includes population frequency data and structural context.
G60E (p.Gly60Glu) variant details
- p.Gly60Glu
- rs1251092701
- NCI-TCGA Cosmic COSV1008
- cosmic curated COSV10087
- gnomAD rs1251092701
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.62
- REVEL 0.58
- MetaLR 0.49
- MetaSVM -0.01
- CADD 25.90
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 6e-05)
- Structural context available