L11P (p.Leu11Pro) variant of ROS1 (P08922)
L11P (p.Leu11Pro) in ROS1 (P08922) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.14 / 1. The record also includes population frequency data and structural context.
L11P (p.Leu11Pro) variant details
- p.Leu11Pro
- ExAC rs772804887
- TOPMed rs772804887
- gnomAD rs772804887
- Missense
- Variant Prioritization Score for Impact Estimate 0.139
- REVEL 0.13
- MetaLR 0.13
- MetaSVM -0.98
- CADD 6.60
- PolyPhen-2 0.00
- SIFT 0.09
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available