C33Y (p.Cys33Tyr) variant of ROS1 (P08922)
C33Y (p.Cys33Tyr) in ROS1 (P08922) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.64 / 1. The record also includes population frequency data and structural context.
C33Y (p.Cys33Tyr) variant details
- p.Cys33Tyr
- Ensembl rs2128753295
- Missense
- Variant Prioritization Score for Impact Estimate 0.641
- REVEL 0.60
- MetaLR 0.52
- MetaSVM 0.06
- CADD 25.80
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the Ashkenazi Jewish population (allele frequency 3.9e-05)
- Structural context available