C6Y (p.Cys6Tyr) variant of ROS1 (P08922)
C6Y (p.Cys6Tyr) in ROS1 (P08922) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
C6Y (p.Cys6Tyr) variant details
- p.Cys6Tyr
- ExAC rs754955040
- gnomAD rs754955040
- Missense
- Variant Prioritization Score for Impact Estimate 0.265
- REVEL 0.07
- MetaLR 0.08
- MetaSVM -1.06
- CADD 17.90
- PolyPhen-2 0.00
- SIFT 0.05
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available