I4V (p.Ile4Val) variant of ROS1 (P08922)
I4V (p.Ile4Val) in ROS1 (P08922) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.09 / 1. The record also includes population frequency data and structural context.
I4V (p.Ile4Val) variant details
- p.Ile4Val
- rs369466253
- ESP rs369466253
- TOPMed rs369466253
- gnomAD rs369466253
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.0873
- REVEL 0.06
- MetaLR 0.08
- MetaSVM -1.04
- CADD 0.01
- PolyPhen-2 0.00
- SIFT 0.36
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available