L34V (p.Leu34Val) variant of ROS1 (P08922)
L34V (p.Leu34Val) in ROS1 (P08922) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data and structural context.
L34V (p.Leu34Val) variant details
- p.Leu34Val
- TOPMed rs1776075738
- Missense
- Variant Prioritization Score for Impact Estimate 0.207
- REVEL 0.07
- MetaLR 0.11
- MetaSVM -0.98
- CADD 17.20
- PolyPhen-2 0.01
- SIFT 0.21
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available