L41R (p.Leu41Arg) variant of ROS1 (P08922)
L41R (p.Leu41Arg) in ROS1 (P08922) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data and structural context.
L41R (p.Leu41Arg) variant details
- p.Leu41Arg
- TOPMed rs1286253504
- gnomAD rs1286253504
- Missense
- Variant Prioritization Score for Impact Estimate 0.418
- REVEL 0.36
- MetaLR 0.24
- MetaSVM -0.48
- CADD 27.20
- PolyPhen-2 0.40
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 4.4e-05)
- Structural context available