I4F (p.Ile4Phe) variant of ROS1 (P08922)
I4F (p.Ile4Phe) in ROS1 (P08922) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data and structural context.
I4F (p.Ile4Phe) variant details
- p.Ile4Phe
- ESP rs369466253
- TOPMed rs369466253
- gnomAD rs369466253
- Missense
- Variant Prioritization Score for Impact Estimate 0.15
- REVEL 0.16
- MetaLR 0.15
- MetaSVM -0.90
- CADD 3.85
- PolyPhen-2 0.19
- SIFT 0.01
- Most common in the REMAINING population (allele frequency 6.6e-05)
- Structural context available