C84F (p.Cys84Phe) variant of ROS1 (P08922)
C84F (p.Cys84Phe) in ROS1 (P08922) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.13 / 1. The record also includes population frequency data and structural context.
C84F (p.Cys84Phe) variant details
- p.Cys84Phe
- cosmic curated COSV10747
- ExAC rs753907292
- TOPMed rs753907292
- gnomAD rs753907292
- Missense
- Variant Prioritization Score for Impact Estimate 0.125
- REVEL 0.03
- MetaLR 0.19
- MetaSVM -0.82
- CADD 12.40
- PolyPhen-2 0.98
- SIFT 0.00
- Population evidence available
- Structural context available