T28K (p.Thr28Lys) variant of ROS1 (P08922)
T28K (p.Thr28Lys) in ROS1 (P08922) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data and structural context.
T28K (p.Thr28Lys) variant details
- p.Thr28Lys
- TOPMed rs924427270
- gnomAD rs924427270
- Missense
- Variant Prioritization Score for Impact Estimate 0.318
- REVEL 0.33
- MetaLR 0.16
- MetaSVM -0.91
- CADD 22.60
- PolyPhen-2 0.41
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available