S36L (p.Ser36Leu) variant of ROS1 (P08922)
S36L (p.Ser36Leu) in ROS1 (P08922) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
S36L (p.Ser36Leu) variant details
- p.Ser36Leu
- gnomAD rs1287982877
- Missense
- Variant Prioritization Score for Impact Estimate 0.225
- REVEL 0.05
- MetaLR 0.07
- MetaSVM -0.99
- CADD 15.20
- PolyPhen-2 0.00
- SIFT 1.00
- Most common in the Latino/Admixed American population (allele frequency 2.5e-05)
- Structural context available