C76Y (p.Cys76Tyr) variant of ROS1 (P08922)
C76Y (p.Cys76Tyr) in ROS1 (P08922) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.67 / 1. The record also includes population frequency data and structural context.
C76Y (p.Cys76Tyr) variant details
- p.Cys76Tyr
- NCI-TCGA Cosmic COSV1008
- cosmic curated COSV10087
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.673
- REVEL 0.65
- MetaLR 0.49
- MetaSVM 0.01
- CADD 32.00
- PolyPhen-2 0.98
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9.4e-07)
- Structural context available