N65S (p.Asn65Ser) variant of ROS1 (P08922)
N65S (p.Asn65Ser) in ROS1 (P08922) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data and structural context.
N65S (p.Asn65Ser) variant details
- p.Asn65Ser
- rs1346089547
- NCI-TCGA Cosmic COSV6385
- cosmic curated COSV63857
- gnomAD rs1346089547
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.25
- REVEL 0.09
- MetaLR 0.14
- MetaSVM -0.94
- CADD 13.00
- PolyPhen-2 0.00
- SIFT 0.08
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available